• Jun Chen, Xue Wang, Yueqian Zhu, Jing He, Yamin Rao, and Ke Liu.
• Department of Dermatology, Shanghai Ninth People's Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Center for Specialty Strategy Research of Shanghai JiaoTong University China Hospital Development Institute, Shanghai 200011, PR China.
• Burns. 2022 Mar 1; 48 (2): 396-403.

BackgroundFew studies have described how the injury affects the nail soft tissue under the nail plate. Nail matrix scar is poorly known.ObjectiveTo establish a stable rat nail loss model in a simple way, and to discuss the comparability of this model.MethodsA sterile cotton swab dipped in a 10% NaOH solution was used to burn the entire nail matrix and bed plane region, and the specimens were examined on day 3, 7, 14, and 28.ResultsAfter avulsion of the nail plate, the eponychia and matrix stuck together without any tissue destruction. On day 28, all claws of the experimental group were observed to be permanently damaged, except for one claw malformed regeneration. All impaired nail regeneration had deficiency or functional loss of NMSCs and shared similar characteristics with the cutaneous scars.ConclusionsThe scar formation of nail matrix was a fundamental reason to nail deficiency of rat or human, providing a research basis for further mechanism or treatment study of nail defect diseases.Copyright © 2021 Elsevier Ltd and ISBI. All rights reserved.

15 keywords...

hide…