• Isabela M Bensenor, Alessandra C Goulart, Alexandre C Pereira, André R Brunoni, Airlane Alencar, Raul D Santos, Márcio S Bittencourt, Rosa W Telles, MachadoLuciana Andrade CarneiroLACClinics Hospital, UFMG, Belo Horizonte, MG, Brazil., Sandhi Maria Barreto, de Almeida-PitittoBiancaBDepartamento de Medicina Preventiva, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Carolina Porto Silva Janovsky, José Augusto Sgarbi, William R Tebar, Vandrize Meneghini, Fernando Barbosa Junior, Ana Cristina de Medeiros Ribeiro, Sandra Gofinet Pasoto, PereiraRosa Maria RRMRLaboratório de Metabolismo Ósseo, Reumatologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Eloísa Bonfá, Aytan M Sipahi, Itamar de S Santos, and Paulo A Lotufo.
• Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Electronic address: isabensenor@gmail.com.
• Clinics (Sao Paulo). 2022 Jan 1; 77: 100013100013.

ObjectivesThis analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones.MethodsA high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox.ResultsThe high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS.ConclusionsThe high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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