• Claire Hentzen, Stefania Musco, Gérard Amarenco, Giulio Del Popolo, and Jalesh N Panicker.
• Groupe de Recherche Clinique en Neuro-Urologie (GREEN), GRC 01, Sorbonne Université, Hôpital Tenon, AP-HP, Paris, France; Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, UK; UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK. Electronic address: claire.hentzen.mpr@gmail.com.
• Lancet Neurol. 2022 Jun 1; 21 (6): 551-562.

AbstractSexual difficulties are common in patients with neurological disorders, and different domains of sexual function-desire, arousal, orgasm, and ejaculation-can be affected. Advances in the past 7 years in structural and functional neuroimaging have contributed to a greater understanding of the neural pathways involved in the regulation of sexual functions in health and disease, and this increased knowledge might help with development of future therapeutic strategies. A comprehensive assessment of patients includes history taking-covering the different domains of dysfunction, and primary, secondary, and tertiary contributory factors-as well as clinical examination in select patients (ie, patients for whom an associated non-neurological cause for sexual dysfunction is suspected). Investigations, such as assessment of associated cardiovascular risk factors, might also be indicated in specific situations. PDE5A inhibitors and intracavernosal injections of the prostaglandin alprostadil are effective for treating erectile dysfunction; however, options for managing other domains of sexual dysfunction in men and women remain poor. Research into different domains of sexual dysfunction is likely to lead to additional therapeutic strategies in the future.Copyright © 2022 Elsevier Ltd. All rights reserved.

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