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- Yuta Baba, Hirotaka Sakai, Nobuyuki Kabasawa, and Hiroshi Harada.
- Division of Hematology, Department of Medicine, Showa University Fujigaoka Hospital, Japan.
- Intern. Med. 2022 Jun 15; 61 (12): 1891-1895.
AbstractSeveral vaccines have been developed for coronavirus disease 2019 - caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - in record time. A few cases of immune thrombocytopenic purpura (ITP) following SARS-CoV-2 vaccination have been reported. We herein report a 90-year-old man who received the Pfizer-BioNTech SARS-CoV-2 vaccine (BNT162b2) and developed severe thrombocytopenia with intracranial hemorrhaging and duodenal bleeding, consistent with vaccine-related ITP. He was successfully treated with intravenous immunoglobulin, prednisolone, and eltrombopag and discharged without cytopenia. Vaccine-related ITP should be suspected in patients presenting with abnormal bleeding or purpura after vaccination.
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