• Medicine · Mar 2020

    Case Reports

    Primary thymic mucosa-associated lymphoid tissue lymphoma complicated with renal amyloidosis: A first case report.

    • Qin Chen, Yongjing Du, Singh Prince, Ping Zhang, Guisen Li, Li Wang, and Wei Wang.
    • Department of Nephrology and Institute of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, China.
    • Medicine (Baltimore). 2020 Mar 1; 99 (13): e19462.

    IntroductionPrimary mucosa-associated lymphoid tissue (MALT) lymphomas originating in thymus is rare. And, there have been few reports of patients with MALT coexisting with amyloidosis. As far as we know, this was the first case report on MALT lymphoma associated with renal amyloidosis.Patient ConcernsA 57-year-old man presented with nephrotic syndrome. Further workup revealed IgM-Lambda type monoclonal gammopathy. Bone marrow biopsy showed 8% clonal plasma cells. Renal biopsy confirmed the diagnosis of Lambda light chain AL amyloidosis. positron emission tomography/computed tomography showed thymic lesions which upon biopsy were diagnosed as MALT lymphoma of the thymus.DiagnosisPrimary thymic MALT lymphoma complicated with renal amyloidosis.InterventionsThe patient underwent surgical resection of the thymus mass and 2 courses of chemotherapy.OutcomesFollow-up data showed that the patient survived 18 months after surgical excision and chemotherapy.ConclusionThe case highlights the importance of screening for malignancy in patients with renal amyloidosis.

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