• Xuejian Gao, Shan Xue, Fuqiang Yang, Baoling Wu, Xiaojing Yu, and Baoquan An.
• Department of Orthopedics, The 80(th) Army Hospital of Chinese People's Liberation Army, Weifang, Shandong, China.
• Clinics (Sao Paulo). 2022 Jan 1; 77: 100034.

ObjectivesTo investigate the expression level and clinical significance of Methyl-CpG binding Protein 2 (MECP2) in elderly patients with hip fractures.MethodsThis prospective observational study included 367 elderly patients with hip fractures between April 2016 and December 2018. All the patients were treated with internal fixation or joint replacement. In addition, 50 healthy elderly individuals were enrolled as healthy controls. The serum levels of MECP2 and inflammatory factors Interleukin (IL)-1β, IL-6, IL-8, and Tumor Necrosis Factor (TNF)-α was determined by enzyme-linked immunosorbent assay. Data on patients' basic characteristics and postoperative complications were collected. The Harris score was used to assess hip function at 1-month, 3-months, and 6-months after surgery. Patient quality of life was measured using the Barthel Index (BI) score 3-months after surgery. The 1-year mortality was analyzed using the Kaplan-Meier curve, and logical regression was used to analyze the risk factors for mortality.ResultsNo significant differences were observed in the basic clinical characteristics of all patients. The serum MECP2 levels were remarkably high in patients with hip fractures and negatively correlated with serum IL-1β, IL-6, and TNF-α levels. Patients with higher MECP2 predicted higher dynamic Harris scores, lower postoperative complications, lower 1-year mortality, and higher BI scores. Logical regression showed that age was the only independent risk factor for postoperative 1-year mortality in elderly patients with hip fractures.ConclusionLower MECP2 predicted poor prognosis and higher 1-year mortality in elderly patients with hip fractures.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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