• Robert N Hensinger.
• Department of Orthopaedic Surgery, Pediatric Orthopaedic Service, The University of Michigan, Ann Arbor, MI 48109, USA. rnh@med.umich.edu
• Spine. 2009 Aug 1; 34 (17): 1745-50.

Study DesignLiterature review.ObjectiveTo provide a current overview of congenital scoliosis and associated conditions.Summary Of Background DataThe etiology of congenital scoliosis is unknown. A variety of factors have been implicated in the development of vertebral abnormalities. These factors provide clues to the origin of congenital scoliosis.MethodsA search of PubMed, using the keywords congenital scoliosis, etiology, and genetics was performed.ResultsEnvironmental factors, genetics, vitamin deficiency, chemicals, and drugs, singly or in combination, have all been implicated in the development of vertebral abnormalities. Whatever the cause, the physiologic injury occurs early in the embryologic period, well before the development of cartilage and bone. The resulting defects can lead to full or partial fusion or lack of development of the vertebrae, which, in turn, can cause a curvature that, may be progressive during the growth of the child.ConclusionThe origin of congenital scoliosis may be environmental, genetic, or a combination of factors. Research on these various factors continues. Early identification and management of concomitant defects can improve the patient's quality of life.

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