• Tony Antoniou, Qi Guan, Diana Martins, and Tara Gomes.
• Li Ka Shing Knowledge Institute (Antoniou, Gomes), Unity Health; Department of Family and Community Medicine (Antoniou), Unity Health; Department of Family and Community Medicine (Antoniou), University of Toronto; Ontario Drug Policy Research Network (Antoniou, Martins, Gomes); Institute for Health Policy, Management and Evaluation (Guan, Gomes), University of Toronto; Leslie Dan Faculty of Pharmacy (Gomes), University of Toronto, Toronto, Ont. Tony.antoniou@unityhealth.to.
• CMAJ. 2022 Apr 19; 194 (15): E542-E548.

BackgroundAccidental acetaminophen overdoses are associated with substantial morbidity and health care costs. In Canada, updated labelling standards were implemented in October 2009 and September 2016, with the intent of communicating risks of overdose and facilitating product identification and safe use, respectively. Full compliance with the 2016 standards was expected by March 2018. We sought to explore whether these changes affected rates of hospital admission for accidental acetaminophen overdose.MethodsWe conducted a population-based study of hospital admissions for accidental acetaminophen overdose in 9 Canadian provinces and 3 Canadian territories between Apr. 1, 2014, and Mar. 31, 2020. We used interventional autoregressive integrated moving average (ARIMA) models to evaluate the impact of the updated labelling standards on rates of hospital admission for accidental acetaminophen overdose. In secondary analyses, we studied intensive care unit (ICU) admissions and hospital admissions for accidental acetaminophen overdose involving opioids.ResultsMonthly rates of hospital admission for accidental acetaminophen overdose were essentially unchanged over the study period (0.21 and 0.22 cases per 100 000 population in April 2004 and March 2020, respectively). We found no association between changing labelling standards and trends in rates of hospital admission for accidental acetaminophen overdose (October 2009 p = 0.2, September 2016 p = 0.7 and March 2018 p = 0.2). Similarly, labelling changes did not have an impact on admissions involving ICU admission and concomitant opioid poisoning.InterpretationModifications to product labels did not reduce the rate of acetaminophen-related harm. Additional measures to reduce the burden of accidental acetaminophen overdose are required.© 2022 CMA Impact Inc. or its licensors.

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