• Anasthesiol Intensivmed Notfallmed Schmerzther · Apr 2022

    [Measurement of Anti-SARS CoV-2 Antibodies following Vaccination: Valuable Monitoring or Irrelevant Tool?]

    • Christopher Lotz, Johannes Herrmann, Martha-Emilia Hübsch, Quirin Notz, and Patrick Meybohm.
    • Anasthesiol Intensivmed Notfallmed Schmerzther. 2022 Apr 1; 57 (4): 302-306.

    AbstractVaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) provides effective protection against infection or severe coronavirus disease 2019 (COVID-19). Moreover, it is regarded as the single most important measure to end the pandemic. Individual vaccination effectiveness is often judged via measurement of anti-SARS-CoV-2 antibodies. However, considering the complexity of the humoral and cellular immune response the question arises whether the relation of anti-SARS-CoV-2 antibody titers and COVID-19 vaccine effectiveness is a myth or a fact? The current article aims to answer this question and provide a short review of the immunological mechanisms of SARS-CoV-2 vaccination. Recommendations for clinical practice are given based on the current evidence and known problems of anti-SARS-CoV-2 antibody measurements after vaccination.Thieme. All rights reserved.

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