• Charles W Goss, Jennifer G Duncan, Sunny S Lou, Katherine J Holzer, Bradley A Evanoff, and Thomas Kannampallil.
• Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.
• J Gen Intern Med. 2022 Apr 1; 37 (5): 120412101204-1210.

BackgroundThe rapid spread of the coronavirus disease 2019 (COVID-19) has created considerable strain on the physical and mental health of healthcare workers around the world. The effects have been acute for physician trainees-a unique group functioning simultaneously as learners and care providers with limited autonomy.ObjectiveTo investigate the longitudinal effects of physician trainee exposure to patients being tested for COVID-19 on stress, anxiety, depression, and burnout using three surveys conducted during the early phase of the pandemic.DesignLongitudinal survey study.ParticipantsAll physician trainees (N = 1375) at an academic medical center.Main MeasureAssess the relationship between repeated exposure to patients being tested for COVID-19 and stress, anxiety, depression, and burnout.Key ResultsThree hundred eighty-nine trainees completed the baseline survey (28.3%). Of these, 191 and 136 completed the ensuing surveys. Mean stress, anxiety, and burnout decreased by 21% (95% confidence interval (CI): - 28 to - 12%; P < 0.001), 25% (95% CI: - 36 to - 11%; P < 0.001), and 13% (95% CI: - 18 to - 7%; P < 0.001), respectively, per survey. However, for each survey time point, there was mean increase in stress, anxiety, and burnout per additional exposure: stress [24% (95% CI: + 12 to + 38%; P < 0.001)], anxiety [22% (95% CI: + 2 to + 46%; P = 0.026)], and burnout [18% (95% CI: + 10 to + 28%; P < 0.001)]. For depression, the association between exposure was strongest for the third survey, where mean depression scores increased by 33% per additional exposure (95% CI: + 18 to + 50%; P < 0.001).ConclusionsTraining programs should adapt to address the detrimental effects of the "pileup" of distress associated with persistent exposure through adaptive programs that allow flexibility for time off and recovery.© 2022. The Author(s) under exclusive licence to Society of General Internal Medicine.

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