• Takaaki Ikeda, Upul Cooray, Masanori Hariyama, Jun Aida, Katsunori Kondo, Masayasu Murakami, and Ken Osaka.
• Department of Health Policy Science, Graduate School of Medical Science, Yamagata University, Yamagata, Yamagata, Japan. tikeda@med.id.yamagata-u.ac.jp.
• J Gen Intern Med. 2022 Aug 1; 37 (11): 272727352727-2735.

BackgroundAdverse health effects resulting from falls are a major public health concern. Although studies have identified risk factors for falls, none have examined long-term prediction of fall risk. Furthermore, recent evidence suggests that there are additional risk factors, such as psychosocial factors.ObjectiveIn this 3-year longitudinal study, we evaluated a predictive model for risk of fall among community-dwelling older adults using machine learning methods.DesignA 3-year follow-up prospective longitudinal study (from 2010 to 2013).SettingTwenty-four municipalities in nine of the 47 prefectures (provinces) of Japan.ParticipantsCommunity-dwelling individuals aged ≥65 years who were functionally independent at baseline (n = 61,883).MethodsThe baseline survey was conducted from August 2010 to January 2012, and the follow-up survey was conducted from October to December 2013. Both surveys were conducted involving self-reported questionnaires. The measured outcome at the follow-up survey was self-reported multiple falls during the previous year. The 142 variables included in the baseline survey were regarded as candidate predictors. The random-forest-based Boruta algorithm was used to select predictors, and the eXtreme Gradient Boosting algorithm with 10 repetitions of nested k-fold cross-validation was used for modeling and model evaluation. Furthermore, we used shapley additive explanations to gain insight into the behavior of the prediction model.Key ResultsFourteen out of 142 candidate features were selected as predictors. Among these predictors, experience of falling as of the baseline survey was the most important feature, followed by self-rated health and age. Moreover, sense of coherence was newly identified as a risk factor for falls.ConclusionsThis study suggests that machine learning tools can be adapted to explore new associative factors, make accurate predictions, and provide actionable insights for fall prevention strategies.© 2022. The Author(s) under exclusive licence to Society of General Internal Medicine.

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