• J Gen Intern Med · May 2022

    Association of Vaccination with the Persistence of Post-COVID Symptoms.

    • Juan P Wisnivesky, Usha Govindarajulu, Emilia Bagiella, Ruchir Goswami, Minal Kale, Kirk N Campbell, Kristin Meliambro, Zijian Chen, Judith A Aberg, and Jenny J Lin.
    • Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    • J Gen Intern Med. 2022 May 1; 37 (7): 174817531748-1753.

    BackgroundPatients who have had COVID-19 often report persistent symptoms after resolution of their acute illness. Recent reports suggest that vaccination may be associated with improvement in post-acute symptoms. We used data from a prospective cohort to assess differences in post-acute sequelae of COVID (PASC) among vaccinated vs. unvaccinated patients.MethodsWe used data from a cohort of COVID-19 patients enrolled into a prospective registry established at a tertiary care health system in New York City. Participants underwent a baseline evaluation before COVID-19 vaccines were available and were followed 6 months later. We compared unadjusted and propensity score-adjusted baseline to 6-month change for several PASC-related symptoms and measures: anosmia, respiratory (cough, dyspnea, phlegm, wheezing), depression, anxiety, post-traumatic stress disorder (PTSD; COVID-19-related and other trauma), and quality-of-life domains among participants who received vs. those who did not receive COVID-19 vaccination.ResultsThe study included 453 COVID-19 patients with PASC, of which 324 (72%) were vaccinated between the baseline and 6-month visit. Unadjusted analyses did not show significant differences in the baseline to 6-month change in anosmia, respiratory symptoms, depression, anxiety, PTSD, or quality of life (p > 0.05 for all comparisons) among vaccinated vs. unvaccinated patients. Similar results were found in propensity-adjusted comparisons and in secondary analyses based on the number of vaccine doses received.ConclusionsOur findings suggest that COVID vaccination is not associated with improvement in PASC. Additional studies are needed to better understand the mechanisms underlying PASC and to develop effective treatments.© 2022. The Author(s) under exclusive licence to Society of General Internal Medicine.

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