• José M Ceresetto, Carlos Tajer, Cristina Duboscq, Federico Bottaro, Patricia Casais, Jorge Korin, Carlos Fondevila, Carla Giumelli, Alejandra Scazziota, Andrea Rossi, Fernando Botto, Maria Ester Ariscancela, Marta Martinuzzo, Ezequiel Zaidel, Mario Fitz Maurice, Cecilia Bahit, Fernando Vazquez, Soledad Molnar, Simón Saizberg, Pedro Negri Aranguren, Claudio Rosa, José Luis Fedele, Pablo Comignani, Gonzalo Pombo, Pablo Raña, Yolanda Adamczuk, Alejandra Martí, Adrián Charask, Diana Penchasky, Dardo Riveros, Javier Mariani, Dolores Puente, Lucia Celebrin, Martín Bosio, Andrés Brodsky, Analía Sanchez Lucero, Yanina Castillo Costa, Alfredo Hirschson, Guillermo Arbesú, Susana Viñuales, Lucía Kazelian, Alberto Maneyro, Victoria Gutierrez, Miguel Castro Rios, Juan Gagliardi, Adrián Lescano, and Fernanda Repetto.
• Hospital Británico de Buenos Aires, Buenos Aires, Argentina. E-mail: jceresetto@intramed.net.
• Medicina (B Aires). 2022 Mar 1; 82 Suppl 2: 1-55.

AbstractDirect oral anticoagulants have emerged as the drugs that have changed the management of the antithrombotic treatment in the last 15 years. Their advantages, like a more friendly way of anticoagulation and their lower risk of bleeding, especially in the brain, have positioned these new anticoagulants as the first drug of choice in the two most frequent indications of anticoagulation, atrial fibrillation, and the venous thromboembolic disease. However, not all the patients can receive these agents, not all the direct oral anticoagulants have the same characteristics, and most importantly, not all the diseases with an indication of an anticoagulant drug can be treated with them. Therefore, it is mandatory that all the faculties involved in the management of these drugs must know them in depth, to decide the best treatment for the patient. This position paper, from a group of experts in anticoagulation in Argentina, can help the general practitioner in the daily use of direct oral anticoagulants based on the new evidence and the experience of a wide group of professionals. The way we relate to the anticoagulant treatment has changed in the last years. The doctors who work with them must also do so.

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