• Hacı Bolat and Aliriza Erdoğan.
• From the Department of General Surgery, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde, Turkey.
• Ann Saudi Med. 2022 Mar 1; 42 (2): 838883-88.

BackgroundThe presence of nodules in the thyroid gland is common in iodine-deficient areas of the world. Recently, vitamin D levels were found to be lower than normal and sometimes deficient in malignant nodules of the thyroid.ObjectiveEvaluate the relationship between the serum vitamin D levels and benign thyroid nodules in euthyroid patients.DesignCross-sectional.SettingTertiary care center in Turkey.Patients And MethodsPatients referred to the general surgery outpatient clinic and diagnosed with thyroid nodules were the study group. The control group consisted of healthy individuals without thyroid nodules. Age, BMI, thyroid ultrasonography, serum 25-hydroxyvitamin D, free T3, free T4, thyroid stimulating hormone, calcium, magnesium, phosphorous, total protein, albumin, glucose, creatinine levels and glomerular filtration rate (GFR) were compared between groups.Main Outcome MeasureSerum 25-hydroxy-vitamin D levels and size of the thyroid nodules.Sample Size And CharacteristicsOf 849 individuals, 453 were patients with thyroid nodules and 396 were healthy individuals.ResultsThe mean serum vitamin D levels of patients with thyroid nodules were significantly lower than controls (P<.001). Serum vitamin D levels along with serum total protein levels and eGFR were independent variables associated with the presence of a thyroid nodule (P<.001, p=.005 and P=.017, respectively).ConclusionThese findings suggest vitamin D deficiency might be one of the pathophysiologic factors in development of thyroid nodules.LimitationSingle-center and possible information bias.Conflicts Of InterestNone.

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