• Qingyu Jiang, Benzhang Tao, Gan Gao, Mengchun Sun, Hui Wang, Junyang Li, Zhongwei Wang, and Aijia Shang.
• Chinese PLA Medical School, Beijing, China.
• World Neurosurg. 2022 Aug 1; 164: 167-176.

AbstractThe conus medullaris is the distal tapering end of the spinal cord, and the filum terminale (FT) is regarded as a bundle of nonfunctional fibrous tissue; therefore, some scholars call it the spinal ligament, while others describe the human FT as "remnants of the spinal cord." It was later found that in the human spinal cord, the FT is composed of an intradural segment and an epidural segment, and the end of the FT is connected to the coccyx periosteum. Because some nerve tissue is also found in the FT, as research progresses, FT may have the potential for transplantation. A lack of exhaustive overviews on the FT in the present literature prompted us to conduct this review. Considering that a current comprehensive review seemed to be the need of the hour, herein, we attempted to summarize previous research and theories on the FT, elucidate its anatomy, and understand its pathological involvement in various diseases.Copyright © 2022. Published by Elsevier Inc.

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