• Mihály K de Bie, Johannes B van Rees, Charles A Herzog, Ton J Rabelink, Martin J Schalij, and J Wouter Jukema.
• Department of Cardiology, Leiden University Medical Center, the Netherlands.
• Curr Med Res Opin. 2011 Jul 1;27(7):1347-57.

BackgroundContrast induced acute kidney injury is an important complication after cardiac (invasive) procedures and is associated with substantial morbidity and mortality. The aim of the current article is to provide a comprehensive overview of the current knowledge regarding contrast induced acute kidney injury.MethodsCurrent literature was reviewed and relevant articles were selected. Articles were identified through MEDLINE and Pubmed selecting articles, limited between 1980 and 2010.ResultsThe pathophysiological process resulting in contrast induced acute kidney injury is not completely understood, nevertheless several mechanisms involved have been proposed. However, the risk factors for contrast induced acute kidney injury and its timing are well known, making it amenable for preventive strategies. In the past decade various preventive strategies have been investigated with different results.ConclusionsCurrently, only adequate hydration, with saline, is uniformly accepted as a beneficial prophylactic strategy. Furthermore promising results have also been reported for several other prophylactic strategies. These results, however, need to be confirmed in future trials.

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