• Ann. Intern. Med. · Jul 2022

    Observational Study

    Association Between SARS-CoV-2 Messenger RNA Vaccines and Lower Infection Rates in Kidney Transplant Recipients : A Registry-Based Report.

    • Ivan Zahradka, Vojtech Petr, Istvan Modos, Maria Magicova, Ladislav Dusek, and Ondrej Viklicky.
    • Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (I.Z., V.P., M.M., O.V.).
    • Ann. Intern. Med. 2022 Jul 1; 175 (7): 961-968.

    BackgroundThe real-world protection provided by SARS-CoV-2 messenger RNA (mRNA) vaccines to kidney transplant recipients (KTRs) remains uncertain.ObjectiveTo study the association between mRNA vaccination and SARS-CoV-2 infection rate in KTRs.DesignRetrospective observational cohort study.SettingThe Czech Republic (17 February to 16 May 2021).Patients2101 KTRs followed in the Department of Nephrology at the Institute for Clinical and Experimental Medicine.MeasurementsPositive result for SARS-CoV-2 on polymerase chain reaction test and vaccination status of KTRs.ResultsThe incidence rate in the vaccinated group was 0.474 per 1000 person-days (33 cases in 69 672 days at risk). The incidence rate in the unvaccinated group was 1.370 per 1000 person-days (79 cases in 57 658 days at risk). The unadjusted incidence rate ratio (IRR; incidence rate of vaccinated/incidence rate of unvaccinated) for KTRs was 0.346 (95% CI, 0.227 to 0.514). The multivariable adjusted IRR for KTRs was 0.544 (CI, 0.324 to 0.876).LimitationRetrospective observational design, uneven follow-up of patient groups, and different exposition to SARS-CoV-2 stemming from strong temporal trends and differences in clinical and probably behavioral characteristics.ConclusionVaccination of KTRs is associated with lower risk for SARS-CoV-2 infection.Primary Funding SourceThe Ministry of Health of the Czech Republic.

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