• Yan-Lin Li, Fang Cheng, Yan Chen, Jun Wang, Zeng-Dong Xiao, and Bin Li.
• Department of Pharmacy, Haibin People's Hospital of Binhai New Area, Binhai New Area, Tianjin, China.
• Medicine (Baltimore). 2022 Apr 15; 101 (15): e29086e29086.

BackgroundRenal anemia (RA) is one of the most common complications in patients with end-stage renal disease, and it is also one of the reasons for the decline of quality of life and functional status in patients with end-stage renal disease. Traditional treatment methods often fail to achieve satisfactory therapeutic effects, so it is very necessary to find effective adjuvant treatment methods. Bailing capsule (BLC), a traditional Chinese medicine, which has been widely used in the treatment of RA in maintenance hemodialysis patients, but a systematic review of the efficacy and safety of this drug is currently lacking. Therefore, this study used meta-analysis to evaluate the efficacy and safety of BLC in the treatment of RA, in order to provide guidance for finding effective auxiliary methods for the treatment of RA in maintenance hemodialysis patients (MHP).MethodsUsing the computer to retrieve PubMed, EMbase, Cochrane Library, CNKI, VIP Database, WANFANG Database, SinoMed from 1990 to 2021 and collecting the clinical randomized controlled trial and retrospective cohort study of BLC in the treatment of RA in MHP. Two researchers independently read and screened the literature, followed by evaluating the retrospective cohort studies that met the selection criteria using the Newcastle-Ottawa Scale (NOS) scale. The randomized controlled trial used the Cochrane manual standards to assess the risk of bias, and the RevMan 5.3 software was used to conduct a meta-analysis of the result data.ResultsThis study will use the method of meta-analysis to evaluate the clinical efficacy and incidence of adverse reactions of BLC in the treatment of RA in MHP through the primary and secondary outcome indicators.ConclusionThe results of this study will help clinicians find safe and effective adjuvant therapy in the treatment of RA in MHP.Osf Registration NumberDOI 10.17605/OSF.IO/732KP (https://osf.io/732kp).Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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