• Jiang-Jiang Wang, Lei Zhang, and Na Cai.
• The First People's Hospital of Jiangxia District, Wuhan City (Union Jiangnan Hospital Huazhong University of Science and Technology), Wuhan, Hubei, China.
• Medicine (Baltimore). 2022 Apr 15; 101 (15): e29109.

BackgroundWhen it comes to preterm newborns, respiratory distress syndrome (RDS) is the most frequent respiratory condition. Despite the fact that it is well acknowledged that preterm delivery plays a significant role, the causes of lung damage are still not completely understood. In newborns with extremely low birth weight and neonatal RDS, nasal continuous positive airway pressure has been suggested as the first respiratory assistance for spontaneous breathing. In the current research, we aim to carry out a meta-analysis to assess the effectiveness and safety of high-flow nasal cannula (HFNC) and non-invasive continuous positive airway pressure (nCPAP) in patients with neonatal respiratory distress syndrome (NRDS).MethodsWe intend to search the following databases: PubMed, EMBASE, Cochrane Library, Wanfang database, China National Knowledge Infrastructure (CNKI), and Google Scholar, starting from their initial publication until February 2022, to identify randomized controlled trials comparing HFNC to nCPAP in patients with NRDS. The suitable papers will be chosen by 2 writers who will work independently of one another. Using the Cochrane updated technique for risk of bias, each included article will be subjected to an independent data extraction process by the 2 writers who will then independently evaluate the risk of bias. Consequently, a third author will be asked to address any discrepancies that may arise between the writers. It will be necessary to pool the data and do a meta-analysis with the help of the RevMan 5.3 software.ResultsIn this study, the effectiveness and safety of HFNC will be compared with those of nCPAP in patients with NRDS.ConclusionIf the results of this research are confirmed, they may serve as a summary of the most recent data for non-invasive respiratory assistance in NRDS.Ethics And DisseminationThe study will require ethical approval.Registration NumberDOI 10.17605/OSF.IO/BKSQ5.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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