• Bin Li, Fei Wen, and Zhaofen Wang.
• Department of Public Health, Medical School of Qinghai University, Xining, China.
• Medicine (Baltimore). 2022 Apr 22; 101 (16): e29127e29127.

BackgroundTo investigate the association between TaqI polymorphism of the vitamin D receptor gene and tuberculosis (TB).MethodsA systematic search was performed in PubMed, Embase, Web of Science, Elsevier Science Direct, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and Chongqing VIP databases for case-control study on TaqI gene polymorphism and TB susceptivity. Quality assessment of studies was performed using the Newcastle-Ottawa Scale for the methodological assessment of case-control studies, and R 4.0.5 software was used for the meta-analysis.ResultsAmong the 243 selected articles, 27 in the meta-analysis. The meta-analysis showed that the TaqI gene polymorphism allene gene model (t vs T, odds ratio [OR]: 1.12, 95% confidence interval [CI]: 0.99-1.27); dominant model (tt + tT vs TT, OR: 1.12, 95% CI: 0.98-1.29); recessive model (tt vs tT + TT, OR: 1.25, 95% CI: 1.03-1.51); codominant A (tt vs TT, OR: 1.37, 95% CI: 1.00-1.87); codominant B (tT vs TT, OR: 1.09, 95% CI: 0.99-1.19). And subgroup dominant model (tt + tT vs TT, OR: 1.27, 95% CI: 1.03-1.55) in Indianas, recessive model (tt vs tT + TT, OR: 1.49, 95% CI: 1.05-2.11) in Iranians, co-dominant B (tT vs TT, OR: 1.28, 95% CI: 1.03-1.59; OR: 1.42, 95% CI: 1.05-1.93) in Indianas and Iranians.ConclusionThis meta-analysis suggests a significant association between TB and the risk of TaqI in Iranians and Indians, but the vitamin D receptor polymorphism TaqI was not associated with Chinese. Thus, validation studies will be required to confirm these findings.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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