• Xiali Teng, Min Jiang, Xiaowei Zhu, Rongrong Dou, Donglan Yuan, Junxing Huang, and Hong Yu.
• Department of Pathology, Taizhou People's Hospital Affiliated to Dalian Medical University, Taizhou, Jiangsu, China.
• Medicine (Baltimore). 2022 Apr 29; 101 (17): e29178e29178.

RationaleThe spleen is an uncommon metastatic organ for malignant solid tumors because of its special anatomy and microenvironment. Isolated splenic metastasis of endometrial cancer is an extremely rare clinical event, with only 17 cases reported in literature.Patient ConcernsWe report the case of a 58-year-old woman with abdominal distension and nausea for 7 months who had undergone surgery and chemotherapy for endometrioid adenocarcinoma 12 years previously. A space-occupying lesion in the upper pole of the spleen was observed on an abdominal ultrasound.DiagnosisThe spleen was resected, and splenic metastasis of endometrial adenocarcinoma was histologically confirmed.InterventionsSplenectomy was performed, and no lymph nodes or other metastases were observed. The patient received postoperative chemotherapy with 6 cycles of docetaxel and carboplatin.OutcomesThe patient recovered well 11 months postoperatively, with no evidence of recurrence or metastatic disease.LessonSince the time interval between the diagnosis of primary endometrial cancer and splenic metastasis may be very long, it may be necessary to monitor the recurrence of endometrial cancer after primary treatment.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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