• Internal medicine · Nov 2022

    Correction of Hypercortisolemia with an Improved Cognitive Function and Muscle Mass after Transsphenoidal Surgery in an Older Patient with Cushing's Disease: A Case Report.

    • Ryo Terayama, Takahiro Ishikawa, Kazuki Ishiwata, Ai Sato, Takuya Minamizuka, Tomohiro Ohno, Satomi Kono, Masashi Yamamoto, Hidetaka Yokoh, Hidekazu Nagano, Masaya Koshizaka, Sawako Suzuki, Hisashi Koide, Yoshiro Maezawa, and Koutaro Yokote.
    • Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Japan.
    • Intern. Med. 2022 Nov 15; 61 (22): 339133993391-3399.

    AbstractCushing's disease causes numerous metabolic disorders, cognitive decline, and sarcopenia, leading to deterioration of the general health in older individuals. Cushing's disease can be treated with transsphenoidal surgery, but thus far, surgery has often been avoided in older patients. We herein report an older woman with Cushing's disease whose cognitive impairment and sarcopenia improved after transsphenoidal surgery. Although cognitive impairment and sarcopenia in most older patients show resistance to treatment, our case indicates that normalization of the cortisol level by transsphenoidal surgery can be effective in improving the cognitive impairment and muscle mass loss caused by Cushing's disease.

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