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- Shuhei Okuyama, Hidetoshi Satomi, Ryuto Ishikawa, Tsutomu Shishido, Keijiro Sato, Toshimitsu Ueki, Masahiko Sumi, and Hikaru Kobayashi.
- Department of Hematology, Nagano Red Cross Hospital, Japan.
- Intern. Med. 2022 Nov 15; 61 (22): 342534293425-3429.
AbstractA 58-year-old man presented with painful edema of the extremities, and a diagnosis of eosinophilic fasciitis (EF) was confirmed. He also met the criteria for hypereosinophilic syndrome (HES), but there were no findings suggestive of malignancies or hematologic neoplasms despite a close examination. He was started on steroid therapy but subsequently developed severe liver dysfunction, hemophagocytic lymphohistiocytosis, hepatosplenomegaly, and renal involvement. The diagnosis of peripheral T-cell lymphoma, not otherwise specified was finally established by a bone marrow reexamination and liver biopsy. In cases of eosinophilia, EF, and/or HES, it is important to suspect an intrinsic abnormality, including potential T-cell lymphoma.
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