• Duleeka Knipe, Prianka Padmanathan, Giles Newton-Howes, Lai Fong Chan, and Nav Kapur.
• Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; South Asian Clinical Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Kandy, Sri Lanka. Electronic address: dee.knipe@bristol.ac.uk.
• Lancet. 2022 May 14; 399 (10338): 1903-1916.

AbstractSuicide and self-harm are major health and societal issues worldwide, but the greatest burden of both behaviours occurs in low-income and middle-income countries. Although rates of suicide are higher in male than in female individuals, self-harm is more common in female individuals. Rather than having a single cause, suicide and self-harm are the result of a complex interplay of several factors that occur throughout the life course, and vary by gender, age, ethnicity, and geography. Several clinical and public health interventions show promise, although our understanding of their effectiveness has largely originated from high-income countries. Attempting to predict suicide is unlikely to be helpful. Intervention and prevention must include both a clinical and community focus, and every health professional has a crucial part to play.Copyright © 2022 Elsevier Ltd. All rights reserved.

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