• Thomas F Hornbein.
• Departments of Anesthesiology and Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington.
• Anesthesiology. 2022 Jul 1; 137 (1): 81-84.

AbstractThe first quantification of neural discharge from the carotid body of cats in response to hypoxia, hypercapnic acidosis, and their combination discovered a strong potentiating effect of hypoxia and hypercapnic acidosis combined as compared to either alone. This paper was the start of a research journey that eventually examined the regulation of blood and cerebrospinal pH by peripheral and central chemoreceptors in the setting of systemic acid-base alterations. This research focus was the result of the author's personal fascination with mountains and human adaptation to high altitude-an interest that led to his own ascent of Mount Everest in 1963. The inherent uncertainty and challenge involved with climbing high mountains has served as a metaphor and inspiration for his life, including his career in academic medicine.Copyright © 2022, the American Society of Anesthesiologists. All Rights Reserved.

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