• Internal medicine · Dec 2022

    A Case of Seronegative Full-house Nephropathy with Crohn's Disease.

    • Hideki Uedono, Akihiro Tsuda, Noriko Ueno, Yuka Natsuki, Rino Nakaya, Kozo Nishide, Yuri Machiba, Kenta Fujimoto, Shinya Nakatani, Katsuhito Mori, and Masanori Emoto.
    • Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.
    • Intern. Med. 2022 Dec 1; 61 (23): 355335583553-3558.

    AbstractSystemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease. Lupus nephritis (LN) is a major risk factor for mortality in SLE, and glomerular "full-house" immunofluorescence staining is a well-known characteristic of LN. However, some cases of non-lupus glomerulonephritis can also present with a "full-house" immunofluorescence pattern. We recently encountered a patient with full-house nephropathy (FHN) during adalimumab administration for Crohn's disease. IgA nephropathy or idiopathic FHN was diagnosed, and treatment with steroids was started, after which there was improvement in proteinuria. The prognosis of FHN has been reported to be poor; therefore, aggressive treatment is required for such patients.

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