• Yuta Nanjo, Tomoko Okuma, Yumi Kuroda, Eri Hayakawa, Kohei Shibayama, Takashi Akimoto, Ryoko Murashima, Koichiro Kanamori, Takeo Tsutsumi, Yohei Suzuki, Yukiko Namba, Fumihiko Makino, Osamu Nagashima, Shinichi Sasaki, and Kazuhisa Takahashi.
• Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Japan.
• Intern. Med. 2022 Jul 15; 61 (14): 2127-2134.

AbstractObjective Based on the increasing incidence of smell and taste dysfunction among coronavirus disease 2019 (COVID-19) patients, such issues have been considered an early symptom of infection. However, few studies have investigated the type of taste components that are most frequently affected in COVID-19 patients. This study investigated the difference in frequencies of the types of taste component disorders among hospitalized COVID-19 patients. Methods In this retrospective, single-center, observational study, patients' background characteristics, clinical course, laboratory and radiological findings, and details on taste and/or smell disorders were collected and analyzed from medical records. Patients A total of 227 COVID-19 patients were enrolled, among whom 92 (40.5%) complained of taste disorders. Results Multiple types of taste disorders (hypogeusia/ageusia and hypersensitivity, or hypersensitivity and changing tastes) were reported in 10 patients. In particular, 23 patients reported hypersensitivity to at least 1 type of taste, and 2 patients complained of a bitter taste on consuming sweet foods. Impairment of all taste components was found in 48 patients (52.2%). The most frequent taste disorder was salty taste disorder (81 patients, 89.0%). Hypersensitivity to salty taste was most frequently observed (19 patients, 20.9%). Conclusion Patients with COVID-19 develop multiple types of taste disorders, among which salty taste disorder was the most frequent, with many patients developing hypersensitivity to salty taste. As smell and taste are subjective senses, further studies with the combined use of objective examinations will be required to confirm the findings.

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