• Internal medicine · Dec 2022

    Case Reports

    Neutrophil Infiltration and Acinar-ductal Metaplasia are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis: A Case Report.

    • Morihisa Hirota, Keigo Murakami, Akinobu Koiwai, Keita Kawamura, Yuki Yoshino, Atsuko Takasu, Ryo Kin, Tomofumi Katayama, Katsuya Endo, Takayuki Kogure, Takayoshi Meguro, Toshiharu Tabata, Kazuhiro Murakami, and Kennichi Satoh.
    • Division of Gastroenterology, Tohoku Medical and Pharmaceutical University, Japan.
    • Intern. Med. 2022 Dec 15; 61 (24): 367536823675-3682.

    AbstractThe histopathological findings of immune checkpoint inhibitor (ICI)-induced pancreatitis have rarely been reported. A 56-year-old man with squamous cell carcinoma of the lung with bone metastasis was being treated with pembrolizumab, an anti-programmed cell death protein-1 antibody. After 13 doses, he was referred to our department due to pancreatitis. Despite characteristic symptoms of acute pancreatitis, imaging findings were similar to those of autoimmune pancreatitis. However, a histological examination showed neutrophil-based inflammatory cell infiltration and acinar-ductal metaplasia. Immunostaining showed CD8-positive T lymphocyte infiltration. This case revealed the characteristic histopathology of pembrolizumab-induced pancreatitis, which was previously poorly understood.

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