• J Palliat Med · Dec 2022

    Case Reports

    Hyponatremia with Antidepressant: A Rare Side Effect from Duloxetine in a Child with Acute Leukemia.

    • Muhammad Usman Baig, Kevin Madden, and Karen Moody.
    • Division of Pediatric Hematology/Oncology, Department of Pediatrics, Loma Linda University, Loma Linda, California, USA.
    • J Palliat Med. 2022 Dec 1; 25 (12): 188418871884-1887.

    AbstractDuloxetine is indicated for the treatment of chemotherapy-induced neuropathic pain in adults. It is also indicated for anxiety, depression, and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults, but not in pediatrics or pediatric oncology patients. We present the case of a 10-year-old child with acute lymphoblastic leukemia, who developed SIADH after duloxetine was given for chemotherapy-induced neuropathic pain and comorbid anxiety. The SIADH resolved after duloxetine was stopped. This case highlights a rare side effect of duloxetine and caution should be taken when prescribing duloxetine to children.

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