• Dtsch. Med. Wochenschr. · Apr 2022

    [Safety and effectiveness of oral anticoagulation in patients with atrial fibrillation and renal insufficiency - a real-world perspective].

    • Uwe Zeymer, Hendrik Bonnemeier, and Christoph Wanner.
    • Medizinische Klinik B, Kardiologie, Pneumologie, Angiologie und Internistische Intensivmedizin; Klinikum der Stadt Ludwigshafen am Rhein.
    • Dtsch. Med. Wochenschr. 2022 Apr 1; 147 (10): 617-624.

    AbstractNon-vitamin-K dependent oral anti-coagulants (NOAC) are the current therapeutic standard for preventing strokes in patients with atrial fibrillation (AF) and should be preferred over vitamin K antagonists (VKA) in this indication. This recommendation applies also to patients with VHF and concomitant chronic kidney disease (CKD). Real World Evidence (RWE), i. e., structured data from clinical practice, extends and confirms the clinical evidence generated in more formalized clinical trials with NOAC and VKA. In addition, RWE in respect to the indication showed that the superiority of NOAC versus the VKA warfarin can also be extrapolated to phenprocoumon, the commonly used VKA in Germany. Furthermore, data include evidence that the typical progression of CKD appears to be less pronounced in individuals treated with NOAC compared to those treated with VKA.Thieme. All rights reserved.

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