• Reg Anesth Pain Med · May 2022

    Review

    Pruritus, neuraxial morphine and recrudescence of oral herpes simplex and treatment: an educational review in obstetric patients.

    • Peter Van de Putte, Jonathan S Jahr, Roland Gieraerts, Jamielynn Hanam-Jahr, and Marc Van de Velde.
    • Anesthesiology, Imeldaziekenhuis, Bonheiden, Belgium.
    • Reg Anesth Pain Med. 2022 May 9.

    AbstractNeuraxial opioids are well known to cause itching, which may be challenging to treat. Neuraxial morphine has been demonstrated to cause recrudescent herpes simplex viruses (HSV-1), especially in women during labor and childbirth with neuraxial analgesia, and may be an occult etiology of refractory itching. This educational review summaries the clinical and epidemiological characteristics associated with recrudescent HSV-1 in patients treated with neuraxial opioids, especially morphine.© American Society of Regional Anesthesia & Pain Medicine 2022. No commercial re-use. See rights and permissions. Published by BMJ.

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