• Laura C Myers, Patricia Kipnis, John Greene, Brian Lawson, Gabriel J Escobar, Bruce H Fireman, Nicola P Klein, and Vincent X Liu.
• Division of Research and The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, California, USA.
• J. Intern. Med. 2022 Aug 1; 292 (2): 377-384.

BackgroundCoronavirus disease 2019 (COVID-19) breakthrough infections are common.ObjectiveEvaluate in-hospital mortality of patients with COVID-19 by vaccination status using retrospective cohort study.MethodsWe generated propensity scores for receipt of full vaccination in adults requiring supplemental oxygen hospitalized at Kaiser Permanente Northern California (1 April 2021 to 30 November 2021) with positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction tests. Optimal matching of fully vaccinated/unvaccinated patients was performed comparing in-hospital mortality.ResultsOf 7305 patients, 1463 (20.0%) were full, 138 (1.9%) were partial, and 5704 (78.1%) were unvaccinated. Fully vaccinated were older than partial or unvaccinated (71.0, 63.0, and 54.0 years, respectively, p < 0.001) with more comorbidities (Comorbidity Point Scores 33.0, 22.0, and 10.0, p < 0.001) and immunosuppressant (11.5%, 8.7%, and 3.0%, p < 0.001) or chemotherapy exposure (2.8%, 0.7%, and 0.4%, p < 0.001). Fewer fully vaccinated patients died compared to matched unvaccinated (9.0% vs. 16.3%, p < 0.0001).ConclusionFully vaccinated patients are less likely to die compared to matched unvaccinated patients.© 2022 The Association for the Publication of the Journal of Internal Medicine.

11 keywords...

hide…