• Reintam BlaserAnnikaAClinic of Anaesthesiology and Intensive Care, Tartu University Hospital, University of Tartu, Tartu, Estonia. annika.reintam@ut.ee, Martijn Poeze, Manu L N G Malbrain, Martin Björck, Oudemans-van StraatenHeleen MHM, Joel Starkopf, and Gastro-Intestinal Failure Trial Group.
• Clinic of Anaesthesiology and Intensive Care, Tartu University Hospital, University of Tartu, Tartu, Estonia. annika.reintam@ut.ee
• Intensive Care Med. 2013 May 1; 39 (5): 899-909.

PurposeThe study aimed to develop a gastrointestinal (GI) dysfunction score predicting 28-day mortality for adult patients needing mechanical ventilation (MV).Methods377 adult patients from 40 ICUs with expected duration of MV for at least 6 h were prospectively studied. Predefined GI symptoms, intra-abdominal pressures (IAP), feeding details, organ dysfunction and treatment were documented on days 1, 2, 4 and 7.ResultsThe number of simultaneous GI symptoms was higher in nonsurvivors on each day. Absent bowel sounds and GI bleeding were the symptoms most significantly associated with mortality. None of the GI symptoms alone was an independent predictor of mortality, but gastrointestinal failure (GIF)--defined as three or more GI symptoms--on day 1 in ICU was independently associated with a threefold increased risk of mortality. During the first week in ICU, GIF occurred in 24 patients (6.4%) and was associated with higher 28-day mortality (62.5 vs. 28.9%, P = 0.001). Adding the created subscore for GI dysfunction (based on the number of GI symptoms) to SOFA score did not improve mortality prediction (day 1 AUROC 0.706 [95% CI 0.647-0.766] versus 0.703 [95% CI 0.643-0.762] in SOFA score alone).ConclusionsAn increasing number of GI symptoms independently predicts 28 day mortality with moderate accuracy. However, it was not possible to develop a GI dysfunction score, improving the performance of the SOFA score either due to data set limitations, definition problems, or possibly indicating that GI dysfunction is often secondary and not the primary cause of other organ failure.

19 keywords...

hide…