• Internal medicine · Jan 2022

    Graves' Disease after Administration of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine in a Type 1 Diabetes Patient.

    • Mayu Sakai, Ken Takao, Takehiro Kato, Kodai Ito, Sodai Kubota, Tokuyuki Hirose, Yanyan Liu, Masami Mizuno, Takuo Hirota, Tetsuya Suwa, Yukio Horikawa, and Daisuke Yabe.
    • Department of Diabetes, Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Japan.
    • Intern. Med. 2022 Jan 1; 61 (10): 156115651561-1565.

    AbstractAlthough there is a great demand for increased coronavirus disease 2019 (COVID-19) vaccination worldwide, rare side effects of the vaccine in susceptible individuals are attracting attention. We recently treated a patient with type 1 diabetes who had HLA-A*240201/A*020101, B*5401/B*5601, DRB1*0405/DRB1*0405, DPB1*0501/DPB1*0501 and DQB1*0401/DQB1*040 and developed Graves' disease soon after the administration of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. While causal relationships between vaccinations and adverse events are difficult to discern due to both confounding and masking factors, our findings suggest that attention to possible adjuvant-related endocrinological diseases in certain individuals receiving SARS-CoV-2 vaccines is appropriate.

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