• Internal medicine · Dec 2022

    Case Reports

    Reversible Periventricular Hyperintensity Lesions in Cerebral Amyloid Angiopathy: A Case Mimicking Cerebral Amyloid Angiopathy-related Inflammation.

    • Yasuteru Inoue, Makoto Nakajima, Yuichiro Inatomi, Teruaki Masuda, Yohei Misumi, Toshiya Nomura, Hiroyuki Uetani, Toshinori Hirai, and Mitsuharu Ueda.
    • Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Japan.
    • Intern. Med. 2022 Dec 1; 61 (23): 358135843581-3584.

    AbstractA 59-year-old man with progressive cognitive decline and mood disturbances was admitted to the hospital. Brain magnetic resonance imaging revealed marked white matter hyperintensity (WMH) and widespread lobar cerebral microbleeds. Because he had untreated hypertension, we started antihypertensive treatment and found a significantly improved cognitive function and WMH regression. We diagnosed him with cerebral amyloid angiopathy (CAA) based on the modified Boston Criteria with the rare apolipoprotein E (ApoE) ε2/ε4 genotype. The mechanism underlying reversible leukoencephalopathy in CAA may be related to the loss of autoregulation of brain circulation: cerebrovascular amyloid β deposits damaged the blood-brain barrier of the capillaries, which led to vasogenic edema induced by blood pressure surges.

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