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- Takashi Oyama, Kazuki Taoka, Akira Chiba, Kensuke Matsuda, Hiroaki Maki, Yosuke Masamoto, and Mineo Kurokawa.
- Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
- Intern. Med. 2022 Dec 1; 61 (23): 357535793575-3579.
AbstractBing-Neel syndrome (BNS) is a rare central nervous system manifestation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM). We herein report a 62-year-old man with LPL/WM after multiple chemotherapies. He had weakness of lower extremities and elevated serum IgM levels. A bone marrow examination showed lymphoplasmacytic cells infiltration. Contrast-enhanced magnetic resonance imaging suggested enhancing lesions in the cauda equina roots. He was diagnosed with BNS and started on treatment with tirabrutinib 480 mg daily. Within three months, he showed clinical and radiologic improvement. Tirabrutinib may have utility as an effective treatment for BNS.
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