• Silvano Filice, Antonio Pavarani, and Davide Cerasti.
• Medical Physics Unit, Azienda Ospedaliero-Universitaria of Parma, Parma, Italy.
• J Neuroimaging. 2022 Jul 1; 32 (4): 604610604-610.

Background And PurposeThis study aims to investigate the feasibility of a "real-time" estimate of the optimal CT perfusion (CTP) acquisition time (Top ) in ischemic stroke patients.MethodsThe arterial input function, the venous output function (VOF), and the time-attenuation curves of ischemic core and ischemic penumbra of 51 patients with acute ischemic stroke in anterior circulation were obtained. The curves were analyzed to determine for each patient the Top value; additionally, several time parameters were derived from each waveform. The relationship between each of these parameters and Top was investigated.ResultsWe found a strong linear correlation between each time parameter derived from VOF curve and Top , suggesting that the VOF waveform is rescaled from patient to patient without significant change in shape.ConclusionsThe linear correlation between Top and the VOF time to peak is well suited to implement a new technique to automatically customize the patient's CTP acquisition time. The method does not require an additional dose of contrast medium and does not increase the overall study time, so its use would be desirable to decrease the average radiation dose.© 2022 American Society of Neuroimaging.

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