• Vitor Santos Cortez, Walter Augusto Moraes, João Victor Taba, Alberto Condi, Milena Oliveira Suzuki, Fernanda Sayuri do Nascimento, Leonardo Zumerkorn Pipek, Vitoria Carneiro de Mattos, Matheus Belloni Torsani, Alberto Meyer, Wu Tu Hsing, and Leandro Ryuchi Iuamoto.
• Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
• Clinics (Sao Paulo). 2022 Jan 1; 77: 100037100037.

AbstractThe objective of this study is to compare the effectiveness of dextrose-prolotherapy with other substances for pain relief in patients with primary knee osteoarthritis. The literature screening was done in January 2021 through Medline (PubMed), EMBASE, and Database of the National Institute of Health based on the following criteria: randomized clinical trials that subjected patients with primary knee osteoarthritis who underwent treatment with dextrose-prolotherapy and other substances for pain relief. Paired reviewers independently identified 3381 articles and included 8 trials that met the eligibility criteria. According to the findings of this review, participants that underwent dextrose-prolotherapy showed improvements between baseline and posterior assessments and when compared to saline injections, but when compared to other substances, the results were not clear. Although dextrose-prolotherapy is a useful treatment method by itself, it is still not possible to clearly affirm that it is superior or inferior to its counterparts. There is an urgent need for further studies to bring more evidence to the field.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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