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Multicenter Study
Critical Stepwise Decline of Antibodies against SARS-CoV-2 among Chronic Hemodialysis Patients 180 Days Post Comirnaty Vaccine.
- Nomy Levin-Iaina, Avital Angel-Korman, Adi Leiba, Esther Peres, Gabriel Bryk, Vladimir Rapoport, Zeev Katzir, Yoram Yagil, and Tal Brosh-Nissimov.
- Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
- Isr Med Assoc J. 2022 May 1; 24 (5): 317-319.
BackgroundThe reduced immune response of maintenance hemodialysis patients to coronavirus disease 2019 (COVID-19) vaccines is a major concern.ObjectivesTo analyze the late (6 months after full vaccination) antibody response and compare it to early post-vaccination titer.MethodsWe conducted a multicenter prospective study of 13 hemodialysis units in Israel.ResultsWe demonstrated that the low titers observed among ESRD patients 2-3 months after vaccination with the Comirnaty vaccine (median 63.8 AU/ml) declined to critically lower values 6 months after full vaccination. (Mediananti S antibodies, 31 AU/ml). Seropositivity significantly declined among hemodialysis patients from 89% to 74% (P < 0.0001), although it did not significantly change among controls.ConclusionsWe recommend all patients on hemodialysis receive a booster COVID-19 vaccine 6 months after the second dose.
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