• Wien. Klin. Wochenschr. · Jun 2023

    Randomized Controlled Trial

    Comparison between exercise therapy and non-hydrolyzed collagen (UC-II) in functionality and quality of life in women with knee osteoarthritis : A randomized controlled clinical trial.

    • Érika Thatyana Nascimento Santana, Saulo da Cunha Machado, Viviane Nascimento Brandão Lima, Valter Joviniano DeSantana Filho, Dos Santos MacielLeonardo YungLYFederal University of Sergipe, UFS, Aracaju, Brazil., Jader Pereira de Farias Neto, CoutinhoHenrique Douglas MeloHDMRegional University of Cariri, URCA, Crato, Brazil. hdmcoutinho@gmail.com., Natália Martins, Monteiro da Silva JúniorWalderiWFederal University of Sergipe, UFS, Aracaju, Brazil., and Lucindo J Quintans Júnior.
    • Federal University of Sergipe, UFS, Aracaju, Brazil.
    • Wien. Klin. Wochenschr. 2023 Jun 1; 135 (11-12): 291300291-300.

    BackgroundKnee osteoarthritis (OA) is characterized by a progressive degeneration of cartilage and menisci, leading to pain and locomotor disability. Here, we aimed to assess the effect of an exercise protocol and the oral use of non-hydrolyzed collagen (UC-II) on the functionality and quality of life of women with knee OA.Material And MethodsIndividuals were divided into three groups (CG [control group]; MG [medication group]; EG [exercise group]). In the CG there was no intervention, while MG received an oral dose (1 capsule/day) of UC-II and the EG held 12 sessions of an exercise protocol.ResultsIn the functionality tests (6-min walk test, 6MWT and timed up and go test [TUG]) the EG (p < 0.001/p = 0.020) and MG (p = 0.010/p = 0.010) revealed a significant improvement when compared to the CG. In the analysis of quality of life by WOMAC, a significant improvement was found only in the EG (p = 0.030) when compared to the CG; the same happened in the stiffness domain (EG, p = 0.010), despite in the pain domain, both the EG (p < 0.001) and the MG (p = 0.060) were better than the CG.ConclusionData obtained here reveal that an exercise protocol and UC-II have similar effects for functionality, despite exercise being superior in promoting the quality of life score.© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

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