• Ramón Fernández Álvarez, Covadonga de la Escosura Muñoz, CuadradoGemma RubinosGRPneumology Service Hospital Universitario Central de Asturias, Oviedo, Spain., UrrutiaMarta IscarMIPneumology Service Hospital Universitario Central de Asturias, Oviedo, Spain., Inés Ruiz Álvarez, María José Vázquez López, Claudia Madrid Carvajal, and Francisco Rodríguez Jerez.
• Pneumology Service Hospital Universitario Central de Asturias, Oviedo, Spain. enelllano@gmail.com.
• Respir Care. 2022 May 24.

BackgroundThe ventilatory mechanics of patients with COPD and obesity-hypoventilation syndrome (OHS) are changed when there is air trapping and auto-PEEP, which increase respiratory effort. P0.1 measures the ventilatory drive and, indirectly, respiratory effort. The aim of the study was to measure P0.1 in subjects with COPD or OHS on treatment with positive pressure and to analyze their changes in P0.1 after treatment.MethodsWith a prospective design, subjects with COPD and OHS were studied in whom positive airway pressure was applied in their treatment. P0.1 was determined at study inclusion and after 6 months of treatment.ResultsA total of 88 subjects were analyzed: 56% were males, and the mean age of 65 ± 9 y old. Fifty-four (61%) had OHS, and 34 (39%) had COPD. Fifty (56%) had air trapping, with an initial P0.1 value of 3.0 ± 1.3 cm H2O compared with 2.1 ± 0.7 cm H2O for subjects who did not have air trapping (P = .001). After 6 months of treatment, subjects who had air trapping had similar P0.1 as those who did not: 2.3 ± 1.1 and 2.1 ± 1 cm H2O, respectively (P = .53). In subjects with COPD, initial P0.1 was 2.9 ± 1.4 cm H2O and at 6 months 2.2 ± 1.1 cm H2O (P = .02). In subjects with OHS, initial P0.1 was 2.4 ± 1.1 cm H2O and at 6 months 2.2 ± 1.0 cm H2O (P = .28).ConclusionsCOPD and air trapping were associated with greater P0.1 as a marker of respiratory effort. A decrease in P0.1 indicates less respiratory effort after treatment.Copyright © 2022 by Daedalus Enterprises.

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