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Support Care Cancer · Sep 2011
Case ReportsHigh doses of oxycodone-naloxone combination may provide poor analgesia.
- Sebastiano Mercadante, Patrizia Ferrera, and Claudio Adile.
- Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy. terapiadeldolore@lamaddalenanet.it
- Support Care Cancer. 2011 Sep 1;19(9):1471-2.
AbstractSeveral studies have shown that an oxycodone/naloxone combination (ratio 2:1) provides analgesia and less constipation in non-cancer patients receiving relatively low doses of this formulation. A case report of a cancer patient who was receiving increasing doses of oxycodone with an unexpected declining analgesia is presented. The substitution with the same doses (240 mg/day) of regular controlled-release oxycodone was effective in regaining adequate analgesia.
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