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- Tomoyo Shimada, Ryota Kamo, Kensuke Daida, Kenya Nishioka, Nobutaka Hattori, and Taiji Tsunemi.
- Department of Neurology, Juntendo University School of Medicine, Japan.
- Intern. Med. 2022 Dec 15; 61 (24): 372337273723-3727.
AbstractWe experienced a young patient who presented with progressive parkinsonism and cerebellar ataxia. Brain magnetic resonance imaging revealed progressive brain calcification, expanding from the bilateral basal ganglia to the central pons, caused by a delayed reaction to the radiation therapy that she had received to treat craniopharyngioma 14 years earlier. Heterogeneous clinical symptoms due to radiation-induced brain calcification have been described, but parkinsonism has never been reported. While dopamine transporter-single photon emission computed tomography revealed only slight damage to the dopaminergic striatal pathway, the extension of calcification to the periventricular white matter was likely responsible for her parkinsonism.
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