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Case Reports
Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions: A Case Report.
- Masaoki Hidaka, Masaya Kumamoto, Tatsuya Suenaga, Ayaka Itsuji, Yuka Kanazawa, Seiji Goto, Hitonori Takaba, and Takanari Kitazono.
- Department of Cerebrovascular Medicine and Neurology, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Japan.
- Intern. Med. 2023 Jan 1; 62 (1): 113118113-118.
AbstractA 30-year-old man admitted with renal dysfunction (serum creatinine, 8.19 mg/dL) was diagnosed with immunoglobulin A nephritis through a renal biopsy. He was treated with intravenous methylprednisolone pulse therapy and urgent hemodialysis, and eventually, he underwent maintenance hemodialysis. On day 108, he developed amnesia. Magnetic resonance imaging revealed bilateral basal ganglia lesions. Wernicke encephalopathy (WE) was diagnosed based on decreased serum thiamine concentration (12.8 μg/dL; reference range, 24-66 μg/dL). Thiamine replacement therapy was initiated, but the Wernicke-Korsakoff syndrome persisted. Careful monitoring of thiamine is required in patients undergoing dialysis. In addition, patients with WE may exhibit bilateral basal ganglia lesions.
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