• Mario Schootman, Cara Wiskow, Travis Loux, Leah Meyer, Shelley Powell, Avi Gandhi, and Alexandre Lacasse.
• SSM Health, Department of Clinical Analytics, 10101 Woodfield Lane, St. Louis, MO 63132, United States of America. Electronic address: mschootman@uams.edu.
• J Crit Care. 2022 Oct 1; 71: 154061.

PurposeTo evaluate the effectiveness of a multidisciplinary, hospital-wide program as part of an electronic sepsis alert tool.Materials And MethodsWe used data from 15 hospitals about adult patients with severe sepsis or septic shock. Nine intervention hospitals implemented an Epic sepsis prediction tool, education, and standardized order sets (six control hospitals did not). A difference-in-difference approach evaluated their effectiveness: 1) pre-implementation period (January 1, 2016-November 15, 2018) and 2) implementation period (November 16, 2018-June 30, 2019).ResultsOutcomes included mortality, receipt of the SEP-1 bundle of care, broad spectrum antibiotic use, ICU stay, and length of stay of 6926 patients. The difference of 6.7 percentage points between the intervention and control groups in SEP-1 bundle completion was not statistically significant (p = 0.105). The increase over time for antibiotic administration ≤1 h of time zero was not larger for hospitals in the intervention group (11.7%) compared to the control-group (7.6%, p = 0.084). Differences among hospitals in both groups were not statistically different for mortality (p = 0.174), ICU stays (p = 0.174), and length of stay (p = 0.652) from pre- to implementation period.ConclusionsThe intervention to facilitate timely sepsis care did not improve patient outcomes among those with severe sepsis or septic shock.Copyright © 2022 Elsevier Inc. All rights reserved.

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