• María Luz Campassi, Fabio Germán Repetto, David María Banegas Litardo, Rocío Castor, Gisela Gómez, Belén Tiseyra, Lucas Flores, Irupe Ramirez, Daniela Maspoli, Jimena Báez, Ivana Boroni, Ramiro Bertola, Elisa Estenssoro, and Arnaldo Dubin.
• Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
• J Crit Care. 2022 Aug 1; 70: 154065.

PurposeTo characterize the incidence, timing, and predictors of augmented renal clearance (ARC) in patients with traumatic brain injury (TBI).Materials And MethodsIn 61 patients with TBI, creatinine clearance (CrCl) was prospectively measured from urine samples, over seven days. ARC was defined as a CrCl >130 mL/min/1.73 m2 in at least one day. We compared patients with and without ARC.ResultsWe performed 295 determinations of CrCl. ARC was present in 82% of the patients and arose in the first 2 days in 86% of them. ARC was more frequent in patients with associated injuries (100 vs. 75%, P = 0.02). There was a trend to a more aggressive resuscitation in patients with ARC but young age was the only independent predictor. Hospital length of stay was higher in ARC (15 [8-25] vs. 6 [3-19] days, P < 0.05).ConclusionsARC is very common and has an early appearance in patients with TBI. Young age is its main determinant.Copyright © 2022 Elsevier Inc. All rights reserved.

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