• Rakesh Ghimire, Pravin Prasad, Subigya Parajuli, Rabin Basnet, Pratik Lamichhane, Nirmal Poudel, Pramesh Sunder Shrestha, Shristi Kharel, Akritee Pokharel, and Anish Mudvari.
• Department of Clinical Pharmacology, Maharajgunj Medical Campus, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
• JNMA J Nepal Med Assoc. 2022 Mar 11; 60 (247): 263-267.

IntroductionDrug interactions are one of the major contributors to increase hospital stay, inflate health care expenses, and cause serious adverse events and end-organ damage. Patients admitted to the intensive care unit are already critically sick and are at greater risk of these adverse outcomes. The study aimed to find out the prevalence of potential drug-drug interactions in the Intensive Care Units of a tertiary care centre.MethodsA descriptive cross-sectional study was conducted among the patients admitted in the Intensive Care Unit of a tertiary care hospital from April-June 2019. Ethical approval was taken from the Institutional Review Board at the institute (Reference number: 399). Convenience sampling method was used. Data was collected using proforma and potential drug-drug interactions were identified using Lexicomp® drug-interactions version 1.1 (Wolters Kluwer). All the drug interactions identified were classified and the severity scale of interactions was also defined. Statistical Package for the Social Sciences version 17.0 was used for data analysis. Point estimate at 95% Confidence Interval was calculated along with frequency, percentage, mean, standard deviation, and mode.ResultsOut of 101 patients, the prevalence of the drug-drug interaction was found to be 90 (89.11%) (83.04-95.18 at 95% Confidence Interval). A total of 490 drug-drug interactions were identified. In severity scale, it was seen that 311 (63.46%) were of moderate severity and 303 (61.83%) of drug interactions were categorised as category C in risk rating.ConclusionsPrevalence of potential drug-drug interactions was higher compared to similar published literature. The most common drug with potential interaction was fentanyl and among pairs was fentanyl plus paracetamol.Keywordsdrug interactions; intensive care units; Nepal; software.

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