• Eduardo Barge-Caballero, Pedro J Marcos-Rodríguez, Nieves Domenech-García, Germán Bou-Arévalo, Javier Cid-Fernández, Raquel Iglesias-Reinoso, Paula López-Vázquez, Javier Muñiz, José M Vázquez-Rodríguez, and María G Crespo-Leiro.
• Servicio de Cardiología, Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, España; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, España; Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, España. Electronic address: eduardo.barge.caballero@sergas.es.
• Med Clin (Barc). 2023 Jan 5; 160 (1): 191-9.

IntroductionStatin therapy might have a beneficial prognostic effect in patients with COVID-19, given its immunomodulative, anti-inflammatory and anti-atherosclerotic properties. Our purpose was to test this hypothesis by using the COVID-19 registry of a Spanish university hospital.MethodsWe conducted a single-center, observational and retrospective study in which hospitalized patients with COVID-19 diagnosed by PCR between March 2020 and October 2020 were included. By means of logistic regression, we designed a propensity score to estimate the likelihood that a patient would receive statin treatment prior to admission. We compared the survival of COVID-19 patients with and without statin treatment by means of Cox regression with inverse probability of treatment weighting (IPTW). The median follow-up was 406 days.ResultsWe studied 1122 hospitalized patients with COVID-19, whose median age was 71years and of which 488 (43.5%) were women. 451 (40.2%) patients received statins before admission. In the IPTW survival analysis, prior statin treatment was associated with a significant reduction in mortality (HR: 0.76; 95%CI: 0.59-0.97). The greatest benefit of previous statin therapy was seen in subgroups of patients with coronary artery disease (HR: 0.32; 95%CI: 0.18-0.56) and extracardiac arterial disease (HR: 0.45; 95%CI: 0.28-0.73).ConclusionsOur study showed a significant association between previous treatment with statins and lower mortality in hospitalized patients with COVID-19. The observed prognostic benefit was greater in patients with previous coronary or extracardiac atherosclerotic disease.Copyright © 2022 Elsevier España, S.L.U. All rights reserved.

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