• Rui-Li Yu, Chen Pan, Ting-Ting Ma, Xiao-Yan Wang, Hai-Yun Shi, Yan Zhuang, Wei-Jun Yan, Jian-Guo Liu, Meng-Da Cao, Jin-Lyu Sun, De-Yun Wang, Jin-Shu Yin, Ji-Fu Wei, and Xue-Yan Wang.
• Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
• J Formos Med Assoc. 2022 Dec 1; 121 (12): 246524802465-2480.

Background/PurposeSpecific immunotherapy is the only effective etiological treatment for allergic rhinitis, but subcutaneous immunotherapy has a slow onset and poor compliance. Predicting the clinical efficacy of subcutaneous immunotherapy in advance can reduce unnecessary medical costs and resource waste. This study aimed to identify metabolites that could predict the efficacy of subcutaneous immunotherapy on seasonal allergic rhinitis by serum metabolomics.MethodsPatients (n = 43) with Artemisia sieversiana pollen allergic rhinitis were enrolled and treated with subcutaneous immunotherapy for one year. Patients were divided into the ineffective group (n = 10) and effective group (n = 33) according to the therapeutic index. Serum samples were collected before treatment. Metabolomics was determined by liquid chromatography-mass spectrometry combined with gas chromatography-mass spectrometry and analyzed differential compounds and related metabolic pathways.ResultsA total of 129 differential metabolites (P < 0.05) were identified and 4 metabolic pathways, namely taurine and hypotaurine metabolism, pentose and glucuronate interconversions, pentose phosphate pathway, and alanine, aspartate, and glutamate metabolism, were involved.ConclusionSome metabolites, such as hypotaurine, taurine, and l-alanine, have the potential to become predictive biomarkers for effective subcutaneous immunotherapy.Copyright © 2022 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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