• Tina-Ioana Bobei, Bashar Haj Hamoud, Romina-Marina Sima, Gabriel-Petre Gorecki, Mircea-Octavian Poenaru, Octavian-Gabriel Olaru, and Liana Ples.
• Department PhD, IOSUD, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
• Medicina (Kaunas). 2022 Apr 25; 58 (5).

AbstractInformation about the impact of SARS-CoV-2 infection on pregnant women is still limited and raises challenges, even as publications are increasing rapidly. The aim of the present study was to determine the impact of SARS-CoV-2 infection on preterm birth pregnancies. We performed a prospective, observational study in a COVID-only hospital, which included 34 pregnant women with SARS-CoV-2 infection and preterm birth compared with a control group of 48 healthy women with preterm birth. The rate of cesarean delivery was 82% in the study group versus 6% for the control group. We observed a strong correlation between premature birth and the presence of COVID-19 symptoms (cough p = 0.029, fever p = 0.001, and chills p = 0.001). The risk for premature birth is correlated to a lower value of oxygen saturation (p = 0.001) and extensive radiologic pulmonary lesions (p = 0.025). The COVID-19 pregnant women with preterm delivery were older, and experienced an exacerbation of severe respiratory symptoms, decreased saturation of oxygen, increased inflammatory markers, severe pulmonary lesions and decreased lymphocytes.

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